148. AptaMetrics: A Web-Based Aptamer Bioinformatics Platform
نویسندگان
چکیده
منابع مشابه
Aptamer Bioinformatics
Aptamers are short nucleic acid sequences capable of specific, high-affinity molecular binding. They are isolated via SELEX (Systematic Evolution of Ligands by Exponential Enrichment), an evolutionary process that involves iterative rounds of selection and amplification before sequencing and aptamer characterization. As aptamers are genetic in nature, bioinformatic approaches have been used to ...
متن کاملAptamer-based thrombin assay on microfluidic platform.
A facile and sensitive aptamer-based protocol has been developed for protein assay on microfluidic platform with fluorescence detection using an off-chip microarray scanner. Aptamer-functionalized magnetic beads were used to capture thrombin that binds to a second aptamer fluorescently labeled by Cy3. Experimental conditions, such as incubation time and temperature, washing time, interfering pr...
متن کاملGalaxy Workflows for Web-based Bioinformatics Analysis of Aptamer High-throughput Sequencing Data
Development of RNA and DNA aptamers for diagnostic and therapeutic applications is a rapidly growing field. Aptamers are identified through iterative rounds of selection in a process termed SELEX (Systematic Evolution of Ligands by EXponential enrichment). High-throughput sequencing (HTS) revolutionized the modern SELEX process by identifying millions of aptamer sequences across multiple rounds...
متن کاملA Web-based Introduction to Bioinformatics - Epistemological Beliefs in Bioinformatics
An OpenLab learning course, taking place in both class room and wet and computer lab, was used to explore the image on bioinformatics reflected by undergraduates and students. Three main aspects were investigated. First, what is their opinion about the bioinformatics working environment? Second, how can biological, mathematical and scientific knowledge increase and third, do epistemological bel...
متن کاملPIBAS FedSPARQL: a web-based platform for integration and exploration of bioinformatics datasets
BACKGROUND There are a huge variety of data sources relevant to chemical, biological and pharmacological research, but these data sources are highly siloed and cannot be queried together in a straightforward way. Semantic technologies offer the ability to create links and mappings across datasets and manage them as a single, linked network so that searching can be carried out across datasets, i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2016
ISSN: 1525-0016
DOI: 10.1016/s1525-0016(16)32957-4